Caffeine-Induced Upregulation of pas-1 and pas-3 Enhances Intestinal Integrity by Reducing Vitellogenin in Aged Caenorhabditis elegans Model
Mijin Lee, Jea Lee, Dongyeon Kim, Hyemin Min, Yhong-Hee Shim, Iain A Brownlee · 2024
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Description
Lee and five co-authors study caffeine and gut aging in a worm model, in work from twenty twenty-four. Intestinal aging brings declining protein control as proteasome activity falls. That decline is a hallmark of age related disease.
Prior work showed caffeine improved gut integrity in aged Caenorhabditis elegans worms by reducing a yolk protein called vitellogenin. The new study traced the regulatory mechanism. Caffeine raised two proteasome related genes, pas-1 and pas-3. Higher proteasome action lowered the yolk protein load. The worm work names a pathway by which a common dietary compound may protect the aging gut.
Catalog record
| CREATOR | Mijin Lee, Jea Lee, Dongyeon Kim, Hyemin Min, Yhong-Hee Shim, Iain A Brownlee |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |