Identification of New Polyacetylenes from Dendropanax morbifera with PPAR-α Activity Study
Donglan Piao, Isoo Youn, Thanh-Hau Huynh, Hyun Woo Kim, Sang Gyun Noh, Hae Young Chung, Dong-Chan Oh, Eun Kyoung Seo, Bartolo Gabriele, Francesco Cacciola · 2024
Read Identification of New Polyacetylenes from Dendropanax morbifera with PPAR-α Activity Study by Donglan Piao, Isoo Youn, Thanh-Hau Huynh, Hyun Woo Kim, Sang Gyun Noh, Hae Young Chung, Dong-Chan Oh, Eun Kyoung Seo, Bartolo Gabriele, Francesco Cacciola (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11677830.txt.
Description
Donglan Piao and co-authors isolated this 2024 set of compounds from a traditional Korean medicinal tree and screened them for metabolic effects. The tree has long treated migraines and period pain. From its aerial parts the team extracted three new polyacetylene compounds plus seven known ones, two of them never before found in this plant family.
Computer docking tested how the ten compounds might grip two metabolic receptors. None much dented one target, but compound seven switched on a fat-burning regulator and its allies in liver cells, behaving like an activator of that pathway. The authors suggest the tree's chemistry could seed treatments aimed at that metabolic switch, while noting only one compound carried the effect.
Catalog record
| CREATOR | Donglan Piao, Isoo Youn, Thanh-Hau Huynh, Hyun Woo Kim, Sang Gyun Noh, Hae Young Chung, Dong-Chan Oh, Eun Kyoung Seo, Bartolo Gabriele, Francesco Cacciola |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |