Mesenchymal Stem Cells and Their Extracellular Vesicles: Therapeutic Mechanisms for Blood–Spinal Cord Barrier Repair Following Spinal Cord Injury
Masahito Nakazaki, Takahiro Yokoyama, Karen L Lankford, Ryosuke Hirota, Jeffery D Kocsis, Osamu Honmou, Monique F Stins · 2024
Read Mesenchymal Stem Cells and Their Extracellular Vesicles: Therapeutic Mechanisms for Blood–Spinal Cord Barrier Repair Following Spinal Cord Injury by Masahito Nakazaki, Takahiro Yokoyama, Karen L Lankford, Ryosuke Hirota, Jeffery D Kocsis, Osamu Honmou, Monique F Stins (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11677717.txt.
Description
Masahito Nakazaki and co-authors review stem cell therapy for spinal cord injury in a 2024 paper. A spinal injury breaks the barrier that guards the cord, letting harmful substances and immune cells flood in. That breach feeds inflammation and blocks regrowth of nerve fibers.
Mesenchymal stem cells, and the tiny parcels they shed, both look able to reseal the barrier. The cells tighten the joins between vessel cells and calm inflammation. The parcels carry much of the same benefit without living cells at all. Animal studies show less leakage, steadier vessels, and better movement after treatment. The authors note that parcel therapy still needs work on dosing and delivery before trials.
Catalog record
| CREATOR | Masahito Nakazaki, Takahiro Yokoyama, Karen L Lankford, Ryosuke Hirota, Jeffery D Kocsis, Osamu Honmou, Monique F Stins |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |