Sulforaphane and Benzyl Isothiocyanate Suppress Cell Proliferation and Trigger Cell Cycle Arrest, Autophagy, and Apoptosis in Human AML Cell Line
Anna Bertova, Szilvia Kontar, Martina Ksinanova, Alberto Yoldi Vergara, Zdena Sulova, Albert Breier, Denisa Imrichova · 2024
Read Sulforaphane and Benzyl Isothiocyanate Suppress Cell Proliferation and Trigger Cell Cycle Arrest, Autophagy, and Apoptosis in Human AML Cell Line by Anna Bertova, Szilvia Kontar, Martina Ksinanova, Alberto Yoldi Vergara, Zdena Sulova, Albert Breier, Denisa Imrichova (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11677715.txt.
Description
Anna Bertova and co-authors tested two plant compounds on leukemia cells in 2024. The compounds, sulforaphane and benzyl isothiocyanate, come from sulfur-rich plants and have wide effects on cells. The test cells were a human acute myeloid leukemia line and a drug-resistant form of it.
Both compounds cut cell survival as dose rose, with the benzyl compound the stronger of the two. Strength was near the same in normal and resistant cells. Both raised a marker of self-digestion in cells, and both pushed more cells into a death-linked phase. Cell death was clearer with the benzyl compound. The authors suggest self-digestion may act as a defense against the death these compounds trigger.
Catalog record
| CREATOR | Anna Bertova, Szilvia Kontar, Martina Ksinanova, Alberto Yoldi Vergara, Zdena Sulova, Albert Breier, Denisa Imrichova |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |