Peptide Hydrogel for Sustained Release of Recombinant Human Bone Morphogenetic Protein-2 In Vitro
Dalin Wang, Guangyan Qi, Mingcai Zhang, Brandon Carlson, Matthew Gernon, Douglas Burton, Xiuzhi Susan Sun, Jinxi Wang · 2024
Read Peptide Hydrogel for Sustained Release of Recombinant Human Bone Morphogenetic Protein-2 In Vitro by Dalin Wang, Guangyan Qi, Mingcai Zhang, Brandon Carlson, Matthew Gernon, Douglas Burton, Xiuzhi Susan Sun, Jinxi Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11677606.txt.
Description
Dalin Wang and seven co-authors tune a peptide gel to drip-feed a bone-growing protein over three weeks. Their 2024 study works in the dish with a lab-made version of a protein used to fuse spines and heal fractures. Its clinical problem is the burst: too much at once causes side effects. Three gel recipes, differing in how much peptide they contain, were loaded with the same dose and sampled for twenty-one days.
The loosest gel, at half peptide, released the protein steadily across the whole run. The two denser gels released far less after the first week, effectively hoarding the dose. The reason showed in the gel's structure: the loose recipe was more porous, swelled less, and was less stiff. The authors conclude the recipe dial controls the release clock, and that the loose version's profile is the one worth testing in animals.
Catalog record
| CREATOR | Dalin Wang, Guangyan Qi, Mingcai Zhang, Brandon Carlson, Matthew Gernon, Douglas Burton, Xiuzhi Susan Sun, Jinxi Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |