Bilosomes and Niosomes for Enhanced Intestinal Absorption and In Vivo Efficacy of Cytarabine in Treatment of Acute Myeloid Leukemia
Abdelrahman R. Said, Mona F. Arafa, Walaa A. El-Dakroury, Sultan Alshehri, Gamal M. El Maghraby · 2024
Read Bilosomes and Niosomes for Enhanced Intestinal Absorption and In Vivo Efficacy of Cytarabine in Treatment of Acute Myeloid Leukemia by Abdelrahman R. Said, Mona F. Arafa, Walaa A. El-Dakroury, Sultan Alshehri, Gamal M. El Maghraby (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11677554.txt.
Description
Abdelrahman Said and co-authors package a leukemia drug for oral use in this 2024 study. Cytarabine works against leukemia but absorbs poorly from the gut and breaks down there. The team loaded it into two kinds of fatty bubbles, niosomes and bile-salt bilosomes.
Both bubble types formed at fine sizes with fair drug loading. Bilosomes released the drug preferentially at gut-like acidity. Perfused rabbit gut absorbed more drug from bubbles, mostly by slipping between cells. In rats with induced leukemia, both forms improved blood counts and cut blast cells versus plain drug solution. The authors present the bubbles as an oral route worth pursuing.
Catalog record
| CREATOR | Abdelrahman R. Said, Mona F. Arafa, Walaa A. El-Dakroury, Sultan Alshehri, Gamal M. El Maghraby |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |