Antibacterial and Anti-Influenza Activities of N-Heterocyclic Carbene–Gold Complexes
Michele Pellegrino, Paola Checconi, Jessica Ceramella, Carla Prezioso, Dolores Limongi, Maria Marra, Annaluisa Mariconda, Alessia Catalano, Marta De Angelis, Lucia Nencioni, Maria Stefania Sinicropi, Pasquale Longo, Stefano Aquaro · 2024
Read Antibacterial and Anti-Influenza Activities of N-Heterocyclic Carbene–Gold Complexes by Michele Pellegrino, Paola Checconi, Jessica Ceramella, Carla Prezioso, Dolores Limongi, Maria Marra, Annaluisa Mariconda, Alessia Catalano, Marta De Angelis, Lucia Nencioni, Maria Stefania Sinicropi, Pasquale Longo, Stefano Aquaro (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11677531.txt.
Description
Michele Pellegrino and co-authors test gold complexes built around carbene ligands against drug-resistant bacteria and influenza virus. Rising resistance makes such metal-based drugs attractive. The team synthesized eight complexes and measured their power against three bacterial species and against flu-infected airway cells.
Three complexes stood out, stopping bacteria at low concentrations. The same three sharply cut the viral load in infected cells, and two of them strongly blocked viral replication. The authors argue these compounds could serve double duty in combined antibacterial and antiviral therapy. That versatility is valuable against infections that no longer answer standard drugs. Further work would be needed before any clinical use.
Catalog record
| CREATOR | Michele Pellegrino, Paola Checconi, Jessica Ceramella, Carla Prezioso, Dolores Limongi, Maria Marra, Annaluisa Mariconda, Alessia Catalano, Marta De Angelis, Lucia Nencioni, Maria Stefania Sinicropi, Pasquale Longo, Stefano Aquaro |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |