Structure Characterization of Zinc Finger Motif 1 and 2 of GLI1 DNA Binding Region
Mousheng Wu, Nusrat Jahan, Amanda Sharp, Anwar Ullah, Corinne E. Augelli-Szafran, Sixue Zhang, Rebecca J. Boohaker · 2024
Read Structure Characterization of Zinc Finger Motif 1 and 2 of GLI1 DNA Binding Region by Mousheng Wu, Nusrat Jahan, Amanda Sharp, Anwar Ullah, Corinne E. Augelli-Szafran, Sixue Zhang, Rebecca J. Boohaker (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11677393.txt.
Description
Mousheng Wu and co-authors solve the structure of a cancer-linked protein's grip in this 2024 study. GLI1 is a transcription factor that switches genes on and misfires in several cancers. It grabs DNA with five zinc finger motifs in a row.
The team crystallized the first two fingers alone. Instead of folding back on themselves, the pair formed a dimer: one molecule's first finger clasped the other's second. That swapped layout differs from the known DNA-bound form. The unique interface may matter for how the protein pairs up off DNA. Structural surprises like this can open new drug angles on a hard target.
Catalog record
| CREATOR | Mousheng Wu, Nusrat Jahan, Amanda Sharp, Anwar Ullah, Corinne E. Augelli-Szafran, Sixue Zhang, Rebecca J. Boohaker |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |