The Improvement in Sleep Quality by Zizyphi Semen in Rodent Models Through GABAergic Transmission Regulation
Mijin Kim, YuJaung Kim, Hyang Woon Lee, Kyung-Mi Kim, Singeun Kim, Seikwan Oh, Takatoshi Kasai · 2024
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Description
Jujube seed has a long folk record as a calmative for poor sleep and anxiety. Mijin Kim and co-authors test its extract in rodents in a 2024 study. They give the extract to mice put to sleep with a drug, and to mice kept awake by caffeine.
The extract lengthened sleep in both tests, with no harm to movement. Brain wave reads in rats showed more deep, non-dream sleep. The extract shifted parts of the brain's GABA system, the main calm signal path. One seed compound raised chloride flow in human cells, an effect blocked by GABA foes. The team ties the sleep gain to that calm path.
Catalog record
| CREATOR | Mijin Kim, YuJaung Kim, Hyang Woon Lee, Kyung-Mi Kim, Singeun Kim, Seikwan Oh, Takatoshi Kasai |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |