Association Between Plasma ADAMTS-7 Levels and Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus
Asimina Ganotopoulou, Emmanouil Korakas, Loukia Pliouta, Aikaterini Kountouri, Sotirios Pililis, Stamatios Lampsas, Ignatios Ikonomidis, Loukianos S Rallidis, Athanasia Papazafiropoulou, Andreas Melidonis, Vaia Lambadiari, Åke Sjöholm · 2024
Read Association Between Plasma ADAMTS-7 Levels and Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus by Asimina Ganotopoulou, Emmanouil Korakas, Loukia Pliouta, Aikaterini Kountouri, Sotirios Pililis, Stamatios Lampsas, Ignatios Ikonomidis, Loukianos S Rallidis, Athanasia Papazafiropoulou, Andreas Melidonis, Vaia Lambadiari, Åke Sjöholm (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11677206.txt.
Description
Asimina Ganotopoulou and co-authors test whether a blood enzyme linked to artery disease also tracks a stiffening of the heart in people with type 2 diabetes, in a 2024 paper. The enzyme, ADAMTS-7, helps remodel tissues and blood vessels and is known to play a part in atherosclerosis, the clogging of arteries. Its tie to heart function was barely studied. The team measured the enzyme in patients' blood and examined their hearts with ultrasound.
The heart problem in view is diastolic dysfunction, where the heart relaxes poorly between beats. That problem rose strongly with age but showed no clear link to enzyme levels. Looking at single ultrasound measures, the enzyme leaned positive only with one timing measure, deceleration time, while age explained most of the rest. The authors say the enzyme's role in this heart problem, and in heart failure among diabetics, needs more study before any verdict.
Catalog record
| CREATOR | Asimina Ganotopoulou, Emmanouil Korakas, Loukia Pliouta, Aikaterini Kountouri, Sotirios Pililis, Stamatios Lampsas, Ignatios Ikonomidis, Loukianos S Rallidis, Athanasia Papazafiropoulou, Andreas Melidonis, Vaia Lambadiari, Åke Sjöholm |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |