Involvement of ATF6 in Octreotide-Induced Endothelial Barrier Enhancement
Saikat Fakir, Nektarios Barabutis, Barbara Ruaro · 2024
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Description
Saikat Fakir and Nektarios Barabutis tested how a drug called octreotide seals the walls of blood vessels, and what role one stress protein plays in that effect. Leaky vessel walls are a hallmark of sepsis and acute lung failure, so drugs that tighten them matter. Octreotide is a lab-made copy of a natural hormone, long used for hormone-secreting tumors. Past work hinted it also guards vessel walls against harm. The team focused on a protein named ATF6.
They used human lung vessel cells and cow lung artery cells, some primed to carry extra ATF6. They then dosed the cells with the drug or a blank control. Tests gauged how much dye leaked through the cell layer, how much harmful oxygen chemistry built up, and which proteins changed. The twenty twenty-four study probes one link in the chain between an old drug and a tighter vessel wall.
Catalog record
| CREATOR | Saikat Fakir, Nektarios Barabutis, Barbara Ruaro |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |