Acetylated Globotetraose (Ac-Gb4) Suppresses Triple-Negative Breast Cancer Through FAK/AKT Signaling Pathway
Yung-Kuo Lee, Misbah Sehar, Lavanya Botcha, Po-Kai Chuang, Farzad Pakdel · 2024
Read Acetylated Globotetraose (Ac-Gb4) Suppresses Triple-Negative Breast Cancer Through FAK/AKT Signaling Pathway by Yung-Kuo Lee, Misbah Sehar, Lavanya Botcha, Po-Kai Chuang, Farzad Pakdel (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11677054.txt.
Description
Yung-Kuo Lee and co-authors tested a sugar-based compound against an aggressive breast cancer in a 2024 study. Triple-negative breast cancer lacks the hormone and growth receptors that standard targeted drugs exploit, so new options are badly needed. The compound is a chemically tweaked version of a cell-surface sugar chain, designed to slip through cell membranes more easily.
In lab dishes, the compound lowered two surface markers on a standard triple-negative cell line and selectively killed the cancer cells while sparing normal breast cells. It slowed growth, triggered cell suicide, and cut the cells' ability to invade, more strongly at higher doses. Protein tests showed it juggled several survival and invasion pathways at once. The authors present the compound as a promising candidate for this hard-to-treat cancer type.
Catalog record
| CREATOR | Yung-Kuo Lee, Misbah Sehar, Lavanya Botcha, Po-Kai Chuang, Farzad Pakdel |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |