Artificial Tertiary Lymphoid Structures: Exploring Mesenchymal Stromal Cells as a Platform for Immune Niche Formation
Ekaterina Zubkova, Alexander Kalinin, Irina Beloglazova, Ella Kurilina, Mikhail Menshikov, Yelena Parfyonova, Zoya Tsokolaeva, Spaska Stanilova · 2024
Read Artificial Tertiary Lymphoid Structures: Exploring Mesenchymal Stromal Cells as a Platform for Immune Niche Formation by Ekaterina Zubkova, Alexander Kalinin, Irina Beloglazova, Ella Kurilina, Mikhail Menshikov, Yelena Parfyonova, Zoya Tsokolaeva, Spaska Stanilova (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676966.txt.
Description
Ekaterina Zubkova and seven colleagues published a 2024 study on building fake lymphoid structures in the lab. Tertiary lymphoid structures are small immune hubs that can form inside tissues. Lab-made versions could help cancer therapy by giving immune cells a base near a tumor.
The team used mesenchymal stromal cells, support cells that can calm or steer immune action. They took these cells from fat tissue. Gene checks at single-cell level found a subgroup that acts like the scaffold cells of real lymph nodes. Such cells drew and organized immune cells in tests. The work is a step toward tailor-made immune niches for patients.
Catalog record
| CREATOR | Ekaterina Zubkova, Alexander Kalinin, Irina Beloglazova, Ella Kurilina, Mikhail Menshikov, Yelena Parfyonova, Zoya Tsokolaeva, Spaska Stanilova |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |