Nerelimomab Alleviates Capsaicin-Induced Acute Lung Injury by Inhibiting TNF Signaling and Apoptosis
Lijuan Huang, Bing Du, Xiaohu Cui, Hanqing Zhao, Yanlin Feng, Ziying Xu, Jianhai Long, Jing Yuan, Fuping You · 2024
Read Nerelimomab Alleviates Capsaicin-Induced Acute Lung Injury by Inhibiting TNF Signaling and Apoptosis by Lijuan Huang, Bing Du, Xiaohu Cui, Hanqing Zhao, Yanlin Feng, Ziying Xu, Jianhai Long, Jing Yuan, Fuping You (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676931.txt.
Description
Lijuan Huang and co-authors report a 2024 study of an antibody drug for lung injury caused by capsaicin. The compound gives chili its heat and is used in riot control sprays. High or long exposure can scar the lungs of police and military staff, and the harm path was unclear.
Gene and protein scans of mouse lung tissue pointed to one swelling pathway as the driver. In mice and in lung cells, the pathway signal rose with worse tissue harm and higher swelling markers. The antibody, which blocks that signal, cut the count of dying cells and lifted a cell guard marker. The work names the pathway as a drug target for this injury.
Catalog record
| CREATOR | Lijuan Huang, Bing Du, Xiaohu Cui, Hanqing Zhao, Yanlin Feng, Ziying Xu, Jianhai Long, Jing Yuan, Fuping You |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |