Exploring the Interaction of 3-Hydroxy-4-pyridinone Chelators with Liposome Membrane Models: Insights from DSC and EPR Analysis
Luísa M. P. F. Amaral, Tânia Moniz, Maria Rangel · 2024
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Description
Luísa Amaral and co-authors probe how a family of metal-grabbing molecules settles into cell-like membranes. The chelators, built on a hydroxy-pyridinone scaffold, were synthesized with alkyl chains of different lengths to tune how fat-loving they are. Artificial liposomes of two common lipids stood in for cell membranes.
Heat-flow measurements showed the hexyl version markedly disturbed the bilayer's melting behavior, a sign of deep interaction. Spin resonance probing then mapped where in the membrane depth the chelators act and how they change fluidity layer by layer. The authors conclude chain length is the master dial for membrane engagement, a design rule for future drugs built on this scaffold that must cross or sit in membranes.
Catalog record
| CREATOR | Luísa M. P. F. Amaral, Tânia Moniz, Maria Rangel |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |