Azobenzene as Multi-Targeted Scaffold in Medicinal Chemistry
Barbara De Filippis, Alice Della Valle, Alessandra Ammazzalorso, Cristina Maccallini, Giuseppe Tesse, Rosa Amoroso, Adriano Mollica, Letizia Giampietro, Sreekantha B Jonnalagadda · 2024
Read Azobenzene as Multi-Targeted Scaffold in Medicinal Chemistry by Barbara De Filippis, Alice Della Valle, Alessandra Ammazzalorso, Cristina Maccallini, Giuseppe Tesse, Rosa Amoroso, Adriano Mollica, Letizia Giampietro, Sreekantha B Jonnalagadda (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676915.txt.
Description
Barbara De Filippis and co-authors review azobenzene, a two-ring chemical scaffold, as a platform for drugs that hit several targets at once, in a 2024 paper. The scaffold is easy to make and easy to vary, so chemists have produced many derivatives. Compounds built on it show a wide spread of effects, from fighting microbes and inflammation to slowing enzymes and cancer cells.
The review walks through the main therapeutic uses and, above all, how small structural changes shift activity. Those structure-activity lessons are the point: they show which tweaks strengthen a chosen effect. The authors aim the survey at chemists designing the next, stronger generation of such drugs.
Catalog record
| CREATOR | Barbara De Filippis, Alice Della Valle, Alessandra Ammazzalorso, Cristina Maccallini, Giuseppe Tesse, Rosa Amoroso, Adriano Mollica, Letizia Giampietro, Sreekantha B Jonnalagadda |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |