Unravelling the Mechanisms of Oxidised Low-Density Lipoprotein in Cardiovascular Health: Current Evidence from In Vitro and In Vivo Studies
Sahsikala Thangasparan, Yusof Kamisah, Azizah Ugusman, Nur Najmi Mohamad Anuar, Nurul ‘Izzah Ibrahim · 2024
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Description
Sahsikala Thangasparan and four co-authors review how oxidized low-density lipoprotein drives cardiovascular disease, in a two thousand twenty-four evidence review. Atherosclerosis, the plaque disease behind most heart deaths, begins with harm to vessel linings and inflammation.
Oxidized LDL stirs both innate and adaptive immunity and sustains the inflammatory signaling, with molecules such as interleukin-6 and tumor necrosis factor alpha, that grows plaques. The review gathers cell culture and animal evidence pathway by pathway, noting where the map of workings still has gaps. Because oxidized LDL sits at the center of triggering and maintaining vessel-lining injury, the authors present it as a hopeful target for more precise anti-atherosclerosis treatments.
Catalog record
| CREATOR | Sahsikala Thangasparan, Yusof Kamisah, Azizah Ugusman, Nur Najmi Mohamad Anuar, Nurul ‘Izzah Ibrahim |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |