In Vitro Screening of an In-House Library of Structurally Distinct Chemotypes Towards the Identification of Novel SARS-CoV-2 Inhibitors
Michele Tonelli, Anna Sparatore, Ivan Bassanini, Valeria Francesconi, Fabio Sparatore, Kevin K. Maina, Serena Delbue, Sarah D’Alessandro, Silvia Parapini, Nicoletta Basilico · 2024
Read In Vitro Screening of an In-House Library of Structurally Distinct Chemotypes Towards the Identification of Novel SARS-CoV-2 Inhibitors by Michele Tonelli, Anna Sparatore, Ivan Bassanini, Valeria Francesconi, Fabio Sparatore, Kevin K. Maina, Serena Delbue, Sarah D’Alessandro, Silvia Parapini, Nicoletta Basilico (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676875.txt.
Description
A home-grown library of drug-like compounds is screened against the COVID-19 virus by Tonelli and co-authors in a 2024 study. Four years after the pandemic began, few drugs reached the market, so the hunt stays urgent. Twenty-five compounds, kin to known anti-infective families, were tested in lab cells.
Each compound was checked for harm to cells and for power to block virus growth. Several compounds blocked the virus at doses that spared the cells. The set spans varied shapes, which widens the chance of a useful lead. Hits from such screens need animal and safety work before any clinic use. The study adds fresh starting points to a thin drug pipeline.
Catalog record
| CREATOR | Michele Tonelli, Anna Sparatore, Ivan Bassanini, Valeria Francesconi, Fabio Sparatore, Kevin K. Maina, Serena Delbue, Sarah D’Alessandro, Silvia Parapini, Nicoletta Basilico |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |