Longitudinal Metabolomics Reveals Metabolic Dysregulation Dynamics in Patients with Severe COVID-19
Ryo Uchimido, Kenjiro Kami, Hiroyuki Yamamoto, Ryo Yokoe, Issei Tsuchiya, Yoko Nukui, Yuki Goto, Mariko Hanafusa, Takeo Fujiwara, Kenji Wakabayashi, Joana Pinto · 2024
Read Longitudinal Metabolomics Reveals Metabolic Dysregulation Dynamics in Patients with Severe COVID-19 by Ryo Uchimido, Kenjiro Kami, Hiroyuki Yamamoto, Ryo Yokoe, Issei Tsuchiya, Yoko Nukui, Yuki Goto, Mariko Hanafusa, Takeo Fujiwara, Kenji Wakabayashi, Joana Pinto (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676849.txt.
Description
Ryo Uchimido and co-authors describe a 2024 study of how body chemistry shifts over time in severe COVID-19. A skewed metabolism is a known part of the disease, but its path across the weeks of severe illness was unclear. The team tracked blood samples from patients on breathing machines in one intensive care unit.
They grouped samples into three spans: the first days, the next two weeks, and the month mark. Hundreds of small molecules were read at each span. Early on, non-survivors showed raised fuel burning across sugar, protein, and fat paths. Later, fat and hormone paths split the groups in fresh ways. Some paths stayed skewed at all spans. The authors say timing shapes what care could target.
Catalog record
| CREATOR | Ryo Uchimido, Kenjiro Kami, Hiroyuki Yamamoto, Ryo Yokoe, Issei Tsuchiya, Yoko Nukui, Yuki Goto, Mariko Hanafusa, Takeo Fujiwara, Kenji Wakabayashi, Joana Pinto |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |