Arginine Hydrochloride Reduce Rectal Mucosal Irritation of Sodium Aescinate: Molecular Docking, Physical Properties, Anti-Hemorrhoidal Activity, Safety and Topical Gel Formulations Investigation
Di Hu, Qiuyang Zeng, Huanrong Wang, Wei Jiang · 2024
Read Arginine Hydrochloride Reduce Rectal Mucosal Irritation of Sodium Aescinate: Molecular Docking, Physical Properties, Anti-Hemorrhoidal Activity, Safety and Topical Gel Formulations Investigation by Di Hu, Qiuyang Zeng, Huanrong Wang, Wei Jiang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676831.txt.
Description
Di Hu and co-authors test whether an amino acid salt can make a rectal drug gentler in this 2024 paper. Sodium aescinate is used on skin to cut inflammation and swelling. Its strong irritation bars use on damaged skin and mucous membranes. The team paired it with arginine hydrochloride in a gel.
Computer docking first checked how the two compounds interact. Gels were then made at several mix ratios and tested for acidity, stability, and spread. Animal tests measured irritation of the rectal lining and anti hemorrhoid effects. A mix ratio of one to six worked best. It cut irritation sharply while keeping the drug action. Safety tests for acute toxicity and skin sensitivity were also run on the chosen gel.
Catalog record
| CREATOR | Di Hu, Qiuyang Zeng, Huanrong Wang, Wei Jiang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |