Improvement of Monacolin K and Pigment Production in Monascus by 5-Azacytidine
Chan Zhang, Haijiao Wang, Qing Sun, Arzugul Ablimit, Huijun Dong, Congcong Wang, Duchen Zhai, Bobo Zhang, Wenlin Hu, Chengjian Liu, Chengtao Wang, Fusheng Chen, Yanchun Shao · 2024
Read Improvement of Monacolin K and Pigment Production in Monascus by 5-Azacytidine by Chan Zhang, Haijiao Wang, Qing Sun, Arzugul Ablimit, Huijun Dong, Congcong Wang, Duchen Zhai, Bobo Zhang, Wenlin Hu, Chengjian Liu, Chengtao Wang, Fusheng Chen, Yanchun Shao (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676827.txt.
Description
Chan Zhang and a large team treat a pigment and cholesterol-lowering compound fungus with a DNA-active drug to raise its yields, in a study from 2024. Monascus molds make prized red pigments and monacolin K, a natural statin relative. Chemical nudges to gene control can wake up production.
Two strains grew heavier and made more red, yellow, and orange pigment after treatment than untreated controls. Monacolin K rose sharply in one strain only. Electron images showed wrinkled surfaces and large bumps on treated threads. The drug is known to shift DNA methylation, which the authors credit for unlocking secondary metabolism.
Catalog record
| CREATOR | Chan Zhang, Haijiao Wang, Qing Sun, Arzugul Ablimit, Huijun Dong, Congcong Wang, Duchen Zhai, Bobo Zhang, Wenlin Hu, Chengjian Liu, Chengtao Wang, Fusheng Chen, Yanchun Shao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |