Oncogenic Functions of Alternatively Spliced MDM2-ALT2 Isoform in Retroperitoneal Liposarcoma
Fernanda Costas C de Faria, Safiya Khurshid, Patricia Sarchet, Sayumi Tahara, Lucia Casadei, Valerie Grignol, Roma Karna, Sydney Rentsch, Nipin Sp, Joal D Beane, Luciano Mazzoccoli, Matias Montes, Giovanni Nigita, Joe T Sharick, Jennifer L Leight, Federica Calore, Dawn S Chandler, Raphael E Pollock, · 2024
Read Oncogenic Functions of Alternatively Spliced MDM2-ALT2 Isoform in Retroperitoneal Liposarcoma by Fernanda Costas C de Faria, Safiya Khurshid, Patricia Sarchet, Sayumi Tahara, Lucia Casadei, Valerie Grignol, Roma Karna, Sydney Rentsch, Nipin Sp, Joal D Beane, Luciano Mazzoccoli, Matias Montes, Giovanni Nigita, Joe T Sharick, Jennifer L Leight, Federica Calore, Dawn S Chandler, Raphael E Pollock, (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676768.txt.
Description
Fernanda Costas de Faria and a large team study an alternatively spliced variant of the MDM2 gene in retroperitoneal liposarcoma, a rare fat cancer of the abdomen. The cancer grows deep in the belly and tends to recur in place, which is what kills patients. Its hallmark is an amplified MDM2 gene. Cells can splice that gene into shorter forms, and one short form, MDM2-ALT2, had no clear role. Their 2024 study measures both forms in patient tissue and tests them in laboratory cells.
Both the full-length gene and the short form ran high in tumors compared with nearby healthy tissue. Cells given extra short form grew, moved, and invaded new ground faster. A growth signaling chain inside the cells fired up in step. When that chain was silenced, the short form's gains fell back. The team reads ALT2 as a driver of spread and a possible drug target.
Catalog record
| CREATOR | Fernanda Costas C de Faria, Safiya Khurshid, Patricia Sarchet, Sayumi Tahara, Lucia Casadei, Valerie Grignol, Roma Karna, Sydney Rentsch, Nipin Sp, Joal D Beane, Luciano Mazzoccoli, Matias Montes, Giovanni Nigita, Joe T Sharick, Jennifer L Leight, Federica Calore, Dawn S Chandler, Raphael E Pollock, |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |