β,β-Difluoro Peroxides as Fluorinated C2-Building Blocks for the Construction of Functionalized Indolizines
Yangyang Ma, Hua Zhang, Xiaoxiao Du, Shurui Fang, Kexin Yin, Gangfeng Du, Zhengshan Tian, Zhonghao Zhou, Bogumil E Brycki · 2024
Read β,β-Difluoro Peroxides as Fluorinated C2-Building Blocks for the Construction of Functionalized Indolizines by Yangyang Ma, Hua Zhang, Xiaoxiao Du, Shurui Fang, Kexin Yin, Gangfeng Du, Zhengshan Tian, Zhonghao Zhou, Bogumil E Brycki (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676711.txt.
Description
Yangyang Ma and co-authors report, in a 2024 paper, a new route to building indolizines, a ring system valued in drug and materials chemistry, using a fluorinated starting block. Their key ingredient is a peroxide carrying two fluorine atoms, which serves as a two-carbon building unit. Paired with pyridinium ylides under mild, base-guided conditions, it closes the second ring in a single annulation step. The trick adds fluorine-bearing decoration that older routes struggle to install.
The method delivered a broad range of multi-substituted indolizines in moderate to good yields. Many useful side groups survived the reaction untouched, widening the menu of products. The authors present the fluorinated peroxide as a fresh building block for this ring family. Such routes help chemists tune the electronic character of ring compounds for screening work.
Catalog record
| CREATOR | Yangyang Ma, Hua Zhang, Xiaoxiao Du, Shurui Fang, Kexin Yin, Gangfeng Du, Zhengshan Tian, Zhonghao Zhou, Bogumil E Brycki |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |