Mass Spectrometry Imaging Reveals Spatial Metabolic Alterations and Salidroside’s Effects in Diabetic Encephalopathy
Shuohan Cheng, Xianyue Meng, Zixuan Wang, Tianfang Lan, Zhi Zhou, Zhonghua Wang, Zeper Abliz · 2024
Read Mass Spectrometry Imaging Reveals Spatial Metabolic Alterations and Salidroside’s Effects in Diabetic Encephalopathy by Shuohan Cheng, Xianyue Meng, Zixuan Wang, Tianfang Lan, Zhi Zhou, Zhonghua Wang, Zeper Abliz (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676703.txt.
Description
Shuohan Cheng and six co-authors photographed the chemistry of diabetic brains, molecule by molecule, to see where the disease rewires metabolism and what a plant compound does about it. Diabetic encephalopathy blurs thinking in long-standing diabetes. They used a mass spectrometry imaging method that maps chemicals across tissue slices. With it they compared the brains of diabetic mice with controls, and with diabetic mice treated for twelve weeks with salidroside.
Twenty-six chemicals differed in the diabetic brains, spanning sugar, amino acid, energy, and fat pathways. Five of them shifted the same way in a second animal model, marking them as candidate biomarkers. Salidroside treatment pushed several disturbed pathways back toward normal, especially sugar handling and fat metabolism. The authors say the spatial maps explain the compound's benefit in anatomical detail. They propose the shared markers as tools for tracking the disease and testing future treatments.
Catalog record
| CREATOR | Shuohan Cheng, Xianyue Meng, Zixuan Wang, Tianfang Lan, Zhi Zhou, Zhonghua Wang, Zeper Abliz |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |