Population Pharmacokinetic and Pharmacodynamic Study of Palbociclib in Children and Young Adults with Recurrent, Progressive, or Refractory Brain Tumors
John C. Panetta, Nicholas S. Selvo, David Van Mater, Clinton F. Stewart · 2024
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Description
John Panetta and co-authors model how a cancer drug moves through the bodies of young patients, in a 2024 study. The drug blocks two cell cycle proteins and is taken by mouth. It was tested in children and young adults whose brain tumors had returned or resisted care.
Data came from thirty-four patients aged about five to twenty-two. The team fit a simple model of intake, spread, and clearing of the drug. A liver value in blood tests tracked with slower clearing. They also modeled how drug levels drove drops in white cells and platelets. Such models help set doses that balance gain and harm for young patients.
Catalog record
| CREATOR | John C. Panetta, Nicholas S. Selvo, David Van Mater, Clinton F. Stewart |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |