Inhibiting De Novo Biosynthesis of Ceramide by L-Cycloserine Can Prevent Light-Induced Retinal Degeneration in Albino BALB/c Mice
Faiza Tahia, Dejian Ma, Daniel J. Stephenson, Sandip K. Basu, Nobel A. Del Mar, Nataliya Lenchik, Harry Kochat, Kennard Brown, Charles E. Chalfant, Nawajes Mandal · 2024
Read Inhibiting De Novo Biosynthesis of Ceramide by L-Cycloserine Can Prevent Light-Induced Retinal Degeneration in Albino BALB/c Mice by Faiza Tahia, Dejian Ma, Daniel J. Stephenson, Sandip K. Basu, Nobel A. Del Mar, Nataliya Lenchik, Harry Kochat, Kennard Brown, Charles E. Chalfant, Nawajes Mandal (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676690.txt.
Description
Tahia and co-authors test whether a drug called L-cycloserine can protect mouse retinas from light damage. The drug blocks new ceramide production, a fat linked to cell death in the retina. Earlier cell work showed it guards light-sensing cells from stress.
Given to albino mice thirty minutes before bright light, the best dose sharply cut cell death. The team tracked how much drug reached the retina and how long it stayed. They also measured fat profiles and genes tied to cell death. The results set up future work on ceramide as a treatment target.
Catalog record
| CREATOR | Faiza Tahia, Dejian Ma, Daniel J. Stephenson, Sandip K. Basu, Nobel A. Del Mar, Nataliya Lenchik, Harry Kochat, Kennard Brown, Charles E. Chalfant, Nawajes Mandal |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |