Anti-Inflammatory Effects of Aptamin C in Pulmonary Fibrosis Induced by Bleomycin
Seulgi Shin, Hyejung Jo, Tomoyo Agura, Seoyoun Jeong, Hyovin Ahn, Soyoung Pang, June Lee, Jeong-Ho Park, Yejin Kim, Jae Seung Kang, Barbara Ruaro · 2024
Read Anti-Inflammatory Effects of Aptamin C in Pulmonary Fibrosis Induced by Bleomycin by Seulgi Shin, Hyejung Jo, Tomoyo Agura, Seoyoun Jeong, Hyovin Ahn, Soyoung Pang, June Lee, Jeong-Ho Park, Yejin Kim, Jae Seung Kang, Barbara Ruaro (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676684.txt.
Description
Seulgi Shin and co-authors test a stabilized vitamin C against lung scarring in mice in this 2024 paper. Plain vitamin C breaks down fast in heat and light. Aptamin C binds it to aptamers, shielding it and helping it into cells. The disease model used bleomycin, a drug that scars mouse lungs much like human fibrosis.
Half the mice on Aptamin C survived, while every mouse on plain vitamin C died. Lung tissue under the microscope showed less inflammation and damage with the stabilized form. The treatment also raised a vitamin C transporter in skin and lung cells. The authors credit better delivery, not just protection, for the stronger effect.
Catalog record
| CREATOR | Seulgi Shin, Hyejung Jo, Tomoyo Agura, Seoyoun Jeong, Hyovin Ahn, Soyoung Pang, June Lee, Jeong-Ho Park, Yejin Kim, Jae Seung Kang, Barbara Ruaro |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |