Prediction of SPT-07A Pharmacokinetics in Rats, Dogs, and Humans Using a Physiologically-Based Pharmacokinetic Model and In Vitro Data
Xiaoqiang Zhu, Weimin Kong, Zehua Wang, Xiaodong Liu, Li Liu, Nuno Vale · 2024
Read Prediction of SPT-07A Pharmacokinetics in Rats, Dogs, and Humans Using a Physiologically-Based Pharmacokinetic Model and In Vitro Data by Xiaoqiang Zhu, Weimin Kong, Zehua Wang, Xiaodong Liu, Li Liu, Nuno Vale (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676658.txt.
Description
Xiaoqiang Zhu and co-authors build a whole-body computer model to predict how a stroke drug candidate travels through rats, dogs, and people. SPT-07A, a form of D-borneol, is in development in China for ischemic stroke. Physiologically based models can forecast blood levels in humans before any volunteer is dosed.
Test-tube studies with liver, kidney, and gut tissue showed the drug is mainly cleared by glucuronidation, a tagging step for excretion. The model, fed those data, first reproduced rat measurements, then scaled to dog and human. A validated ladder like this de-risks first-in-human dosing and can trim animal testing along the way.
Catalog record
| CREATOR | Xiaoqiang Zhu, Weimin Kong, Zehua Wang, Xiaodong Liu, Li Liu, Nuno Vale |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |