Single-Cell RNA Sequencing, Cell Communication, and Network Pharmacology Reveal the Potential Mechanism of Senecio scandens Buch.-Ham in Hepatocellular Carcinoma Inhibition
Jiayi Jiang, Haitao Wu, Xikun Jiang, Qing Ou, Zhanpeng Gan, Fangfang Han, Yongming Cai, Olaf-Georg Issinger · 2024
Read Single-Cell RNA Sequencing, Cell Communication, and Network Pharmacology Reveal the Potential Mechanism of Senecio scandens Buch.-Ham in Hepatocellular Carcinoma Inhibition by Jiayi Jiang, Haitao Wu, Xikun Jiang, Qing Ou, Zhanpeng Gan, Fangfang Han, Yongming Cai, Olaf-Georg Issinger (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676315.txt.
Description
Jiayi Jiang and co-authors hunted for how a traditional plant might fight liver cancer, in a 2024 paper. The plant, climbing senecio, is bitter and has shown anti-tumor hints. The team combined network pharmacology with single-cell data. They gathered the plant's active ingredients from four databases, predicted their targets, and crossed those with genes that misbehave in liver tumors drawn from public expression datasets.
Eleven ingredients and hundreds of targets emerged, narrowing to seven core genes. Single-cell maps showed where those targets sit among tumor cell clusters. The team checked the candidates with survival analysis, immune infiltration patterns, and molecular docking, which tests how snugly a compound fits its target. Cell communication analysis added context. The authors present the network as a hypothesis map for experiments, in a cancer that badly needs new options.
Catalog record
| CREATOR | Jiayi Jiang, Haitao Wu, Xikun Jiang, Qing Ou, Zhanpeng Gan, Fangfang Han, Yongming Cai, Olaf-Georg Issinger |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |