Mesoporous Polydopamine Nano-Bowls Demonstrate a High Entrapment Efficiency and pH-Responsive Release of Paclitaxel for Suppressing A549 Lung Cancer Cell Proliferation In Vitro
Lindokuhle M. Ngema, Shahinur Acter, Samson A. Adeyemi, Thashree Marimuthu, Mershen Govender, Wilfred Ngwa, Yahya E. Choonara · 2024
Read Mesoporous Polydopamine Nano-Bowls Demonstrate a High Entrapment Efficiency and pH-Responsive Release of Paclitaxel for Suppressing A549 Lung Cancer Cell Proliferation In Vitro by Lindokuhle M. Ngema, Shahinur Acter, Samson A. Adeyemi, Thashree Marimuthu, Mershen Govender, Wilfred Ngwa, Yahya E. Choonara (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676260.txt.
Description
Ngema and six colleagues build bowl shaped carriers to deliver a lung cancer drug in twenty twenty-four. Paclitaxel treats non small cell lung cancer, but it clears from the body poorly and causes side effects. A better carrier could aim the drug at tumor cells. The team made porous bowls from polydopamine, a sticky polymer.
The bowls had hollow centres and tiny channels for loading the drug. Loading captured about ninety-six percent of the drug used. About eighty-five percent was released in acidic fluid mimicking tumor conditions. Release blended diffusion and polymer relaxation mechanisms. Treated lung cancer cells mostly died within two to three days. Cell viability fell to about fourteen percent at forty-eight hours at the top dose. The authors propose the bowls as an improved delivery system.
Catalog record
| CREATOR | Lindokuhle M. Ngema, Shahinur Acter, Samson A. Adeyemi, Thashree Marimuthu, Mershen Govender, Wilfred Ngwa, Yahya E. Choonara |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |