The Gut–Heart Axis: Effects of Intestinal Microbiome Modulation on Cardiovascular Disease—Ready for Therapeutic Interventions?
Alexandra Sagmeister, Christian M. Matter, Barbara E. Stähli, Michael Scharl · 2024
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Description
Alexandra Sagmeister and three co-authors review trials on the gut-heart axis in this 2024 paper. The axis is the two way link between gut microbes and the heart and blood vessels. Certain gut bacteria and their products have been tied to the start and growth of heart disease. The team asked whether changing the gut microbiome can prevent or treat that disease.
Their review covers randomized trials from August 2018 to August 2023. Lifestyle steps and probiotics showed the clearest gains. The diets with the best support were Mediterranean, high fiber, polyphenol rich, and rich in unsaturated fats. Among drugs, only empagliflozin showed clear gains on risk factors. Many diet trials were small or short, so their results stayed mixed. Effects on hard outcomes, like heart attacks, remain unknown.
Catalog record
| CREATOR | Alexandra Sagmeister, Christian M. Matter, Barbara E. Stähli, Michael Scharl |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |