Improving the Anti-Tumor Effect of Indoleamine 2,3-Dioxygenase Inhibitor CY1-4 by CY1-4 Nano-Skeleton Drug Delivery System
Hui Li, Junwei Liu, Jingru Wang, Zhuoyue Li, Jianming Yu, Xu Huang, Bingchuan Wan, Xiangbao Meng, Xuan Zhang · 2024
Read Improving the Anti-Tumor Effect of Indoleamine 2,3-Dioxygenase Inhibitor CY1-4 by CY1-4 Nano-Skeleton Drug Delivery System by Hui Li, Junwei Liu, Jingru Wang, Zhuoyue Li, Jianming Yu, Xu Huang, Bingchuan Wan, Xiangbao Meng, Xuan Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676189.txt.
Description
Hui Li and eight co-authors rescue a cancer drug candidate that barely dissolves in water. CY1-4 blocks indoleamine 2,3-dioxygenase, an immune brake tumors exploit, but poor solubility tanks its absorption. The team loaded the drug into a mesoporous silica nano-skeleton, then coated it with two hydrophilic materials. Inside the carrier the drug sat in amorphous form.
Solubility jumped about 200 times, and oral absorption rose roughly 24-fold against a plain suspension given at a higher dose. In mice bearing melanoma, the system slowed tumor growth, stretched survival, and cut enzyme activity in blood and tumor. Immune effects matched the intended mechanism.
Catalog record
| CREATOR | Hui Li, Junwei Liu, Jingru Wang, Zhuoyue Li, Jianming Yu, Xu Huang, Bingchuan Wan, Xiangbao Meng, Xuan Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |