Differential TLR-ERK1/2 Activity Promotes Viral ssRNA and dsRNA Mimic-Induced Dysregulated Immunity in Macrophages
Rakshya Shrestha, Paige Marie Johnson, Roshan Ghimire, Cody John Whitley, Rudragouda Channappanavar · 2024
Read Differential TLR-ERK1/2 Activity Promotes Viral ssRNA and dsRNA Mimic-Induced Dysregulated Immunity in Macrophages by Rakshya Shrestha, Paige Marie Johnson, Roshan Ghimire, Cody John Whitley, Rudragouda Channappanavar (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676137.txt.
Description
Rakshya Shrestha and four co-authors study how TLR and ERK signaling drive dysregulated immunity in macrophages in a 2024 paper. RNA viruses can spark too much inflammation while the interferon reply that should stop them runs weak. That split response goes with severe disease, yet the host switches behind it were poorly mapped.
The team fed mouse macrophages fake viral RNA of both kinds: single-stranded, which trips one toll-like receptor, and double-stranded, which trips another. The two alarms drove unlike patterns of the ERK pathway and unlike mixes of signals. The split in that one pathway, they argue, helps explain how the immune reply goes off the rails.
Catalog record
| CREATOR | Rakshya Shrestha, Paige Marie Johnson, Roshan Ghimire, Cody John Whitley, Rudragouda Channappanavar |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |