Deciphering Immune Modulation in Chickens Co-Infected with ALV-J and CIAV: A Transcriptomic Approach
Sheng Chen, Huijuan Xu, Wenxue Li, Yu Nie, Qingmei Xie, Weiguo Chen, Paolo Calistri · 2024
Read Deciphering Immune Modulation in Chickens Co-Infected with ALV-J and CIAV: A Transcriptomic Approach by Sheng Chen, Huijuan Xu, Wenxue Li, Yu Nie, Qingmei Xie, Weiguo Chen, Paolo Calistri (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676111.txt.
Description
Sheng Chen and co-authors study what happens when two viruses infect chickens at the same time. One virus causes a form of avian leukosis and the other causes infectious anemia; together they weaken the birds' defenses, invite further infections, and blunt vaccines. The team used gene-activity profiling to find which genes and pathways change when both viruses strike together.
The scan found about a thousand changed messenger RNAs and dozens of changed small RNAs tied to the joint effect. The immune suppression in co-infected birds may run through heavier use of reactive oxygen and stress pathways. The pair of viruses also seems to dodge immunity by reshaping how the cell handles its RNA, a route that differs from single infections. The authors say the findings can guide targeted treatments and better disease control in poultry, where such co-infections cost the industry heavily each year.
Catalog record
| CREATOR | Sheng Chen, Huijuan Xu, Wenxue Li, Yu Nie, Qingmei Xie, Weiguo Chen, Paolo Calistri |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |