New Benzofuran–Pyrazole-Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, DNA Gyrase B Inhibition, and In Silico Studies
Somaia S Abd El-Karim, Manal M Anwar, Yasmin M Syam, Hassan M Awad, Asmaa Negm El-Dein, Mohamed K El-Ashrey, Hamad M Alkahtani, Sameh H Abdelwahed, Poce Giovanna · 2024
Read New Benzofuran–Pyrazole-Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, DNA Gyrase B Inhibition, and In Silico Studies by Somaia S Abd El-Karim, Manal M Anwar, Yasmin M Syam, Hassan M Awad, Asmaa Negm El-Dein, Mohamed K El-Ashrey, Hamad M Alkahtani, Sameh H Abdelwahed, Poce Giovanna (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11676098.txt.
Description
Germs that resist standard drugs are a growing threat, so new drug designs are badly needed. Somaia Abd El-Karim and co-authors built a new set of fused-ring compounds and tested them in this 2024 study. The design joins two known drug parts and aims at an enzyme that germs need to copy their genes.
Lab tests checked how well the new compounds killed a range of germs and fungi, and how well they calmed swelling and mopped up harmful free molecules. Several compounds worked at low doses across many germs. The strongest ones also blocked the target enzyme in tests, and computer models backed up the design. The paper gives drug makers a fresh lead set, though all the work so far is in the lab, not in patients.
Catalog record
| CREATOR | Somaia S Abd El-Karim, Manal M Anwar, Yasmin M Syam, Hassan M Awad, Asmaa Negm El-Dein, Mohamed K El-Ashrey, Hamad M Alkahtani, Sameh H Abdelwahed, Poce Giovanna |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |