Antibiofilm, Anti-Inflammatory, and Regenerative Properties of a New Stable Ozone-Gel Formulation
Carla Russo, Giuseppe Curcio, Alessandro Graziani, Antonella Mencacci, Donatella Pietrella · 2024
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Description
Carla Russo and four co-authors test a stable ozone gel against the three problems that stall chronic skin wounds: germs, inflammation, and dead tissue. Ozone kills microbes powerfully, but most preparations fade fast. This gel keeps its strength for over thirty months. The team measured its killing power, its effect on bacterial biofilms, its calming of inflammation, and its help in closing scratches in cultured skin cells.
The gel killed every reference microbe tested and most clinical isolates, and stronger doses could break up biofilms that had already formed. It lowered production of an inflammatory signal, TNF-alpha, in cell tests. In scratch assays it sped the regrowth of both fibroblasts and keratinocytes, the two skin cell types that rebuild a wound. The authors propose the gel for advanced wound care.
Catalog record
| CREATOR | Carla Russo, Giuseppe Curcio, Alessandro Graziani, Antonella Mencacci, Donatella Pietrella |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |