Buccal Absorption of Biopharmaceutics Classification System III Drugs: Formulation Approaches and Mechanistic Insights
Rayan Sabra, Daniel Kirby, Vikram Chouk, Kleta Malgorzata, Afzal R Mohammed, Antonio Lopalco · 2024
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Description
Rayan Sabra, Daniel Kirby, Vikram Chouk, and a wider team wrote this review paper, published in 2024. It looks at giving drugs through the inside of the cheek, focusing on a class of drugs that dissolve well in water but pass poorly through body tissues.
Drugs in this class are hard to get into the blood, so new delivery tricks matter. The review walks through several of them. Some chemicals loosen tissue barriers. Sticky polymers hold a dose in place. Other tricks tweak acidity, pair drugs with carrier molecules, or use prodrugs that change form in the body. For each trick, the authors explain how it should raise absorption. They argue that pairing these tricks with standard cheek dosage forms could lift how much drug reaches the blood.
Catalog record
| CREATOR | Rayan Sabra, Daniel Kirby, Vikram Chouk, Kleta Malgorzata, Afzal R Mohammed, Antonio Lopalco |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |