Thermally Solvent-Free Cross-Linked pH/Thermosensitive Hydrogels as Smart Drug Delivery Systems
Sanda Bucatariu, Bogdan Cosman, Marieta Constantin, Gabriela Liliana Ailiesei, Daniela Rusu, Gheorghe Fundueanu, Célio Fernandes, Sérgio Veloso, Enrico Gallo, Carlo Diaferia · 2024
Read Thermally Solvent-Free Cross-Linked pH/Thermosensitive Hydrogels as Smart Drug Delivery Systems by Sanda Bucatariu, Bogdan Cosman, Marieta Constantin, Gabriela Liliana Ailiesei, Daniela Rusu, Gheorghe Fundueanu, Célio Fernandes, Sérgio Veloso, Enrico Gallo, Carlo Diaferia (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11675986.txt.
Description
A smart drug carrier should release its cargo only where the body signals trouble, such as a shift in acidity or temperature. Sanda Bucatariu and co-authors built a hydrogel that pairs an acid-sensing polymer with a heat-sensing one, cross-linked without solvents by a thermal route. The acid-sensitive part acts as a sensor, and the heat-sensitive part as the delivery muscle that squeezes out the drug.
Tests with infrared and magnetic resonance methods confirmed the gel's structure. Oddly, the gel lost its heat response under body-like conditions, then regained it when certain natural biomolecules latched onto its acid-sensing units. That switch is the point: a disturbed body signal could restore the squeeze and shape how the drug releases. The authors frame the gel as a step toward carriers that react to illness itself.
Catalog record
| CREATOR | Sanda Bucatariu, Bogdan Cosman, Marieta Constantin, Gabriela Liliana Ailiesei, Daniela Rusu, Gheorghe Fundueanu, Célio Fernandes, Sérgio Veloso, Enrico Gallo, Carlo Diaferia |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |