Circumventing the Impossible: Cell-Free Synthesis of Protein Toxins for Medical and Diagnostic Applications
Alina Mai Woelbern, Franziska Ramm, Tamás Mészáros · 2024
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Description
Alina Mai Woelbern, Franziska Ramm, and Tamás Mészáros review making protein toxins without living cells in this 2024 paper. Toxins come from bacteria, fungi, plants, and animal venom, and they harm host cells. Yet that very harm can be useful in medicine, and good knowledge of a toxin is needed to build drugs or defenses.
Growing toxins in living cells needs strict safety and often gives low yields, because the toxin kills its host. The review covers a method that uses cell extracts instead of living cells, which sidesteps both problems. It sets out recent gains in making toxins this way and their uses in drug and test work.
Catalog record
| CREATOR | Alina Mai Woelbern, Franziska Ramm, Tamás Mészáros |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |