Epigenome-Wide and Methylation Risk Score Analysis of Body Mass Index Among People with HIV
Nanzha Abi, Alexandra Young, Pradeep Tiwari, Junyu Chen, Chang Liu, Qin Hui, Kaku So-Armah, Matthew S Freiberg, Amy C Justice, Ke Xu, Marta Gwinn, Vincent C Marconi, Yan V Sun, Assam El-Osta, Andrea Fuso · 2024
Read Epigenome-Wide and Methylation Risk Score Analysis of Body Mass Index Among People with HIV by Nanzha Abi, Alexandra Young, Pradeep Tiwari, Junyu Chen, Chang Liu, Qin Hui, Kaku So-Armah, Matthew S Freiberg, Amy C Justice, Ke Xu, Marta Gwinn, Vincent C Marconi, Yan V Sun, Assam El-Osta, Andrea Fuso (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11675887.txt.
Description
Weight gain in people with HIV may leave marks on their DNA, and Nanzha Abi and co-authors search for those marks in this 2024 study. Modern HIV therapy keeps the virus in check but often adds weight, raising diabetes and heart risks. The team asked whether chemical tags on DNA track body mass in this group.
The study scanned DNA tags across the genome in 892 African American men with HIV from a veterans' cohort. Four sites stood out, including one in a gene called RAP1B. Some marks matched those seen in people without HIV, while others were distinct. A combined score built from the marks explained about nineteen percent of weight differences.
Catalog record
| CREATOR | Nanzha Abi, Alexandra Young, Pradeep Tiwari, Junyu Chen, Chang Liu, Qin Hui, Kaku So-Armah, Matthew S Freiberg, Amy C Justice, Ke Xu, Marta Gwinn, Vincent C Marconi, Yan V Sun, Assam El-Osta, Andrea Fuso |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |