HMGA1 Plays a Role in Counteracting DNA Damage Induced by BoHV-1 Productive Infection
Heci Zhao, Xiaotian Fu, Xiuyan Ding, Liqian Zhu · 2024
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Description
Heci Zhao, Xiaotian Fu, Xiuyan Ding, and Liqian Zhu studied how a cell protein helps cattle cells resist DNA damage caused by a bovine herpesvirus, in this 2024 paper. The virus's growth breaks DNA strands, which can push cells toward death. A repair protein gathers at the breaks to start fixing them, and the team asked whether the protein HMGA1 backs that defense.
When they blocked HMGA1 with gene silencing or a drug, virus-driven DNA damage got worse, marking HMGA1 as part of the counterattack. HMGA1 also interacts with the repair protein and shapes how much of it gathers in the nucleus, though infection flips part of that effect. The authors say the defense seems to run partly through other routes, and the fine details remain open.
Catalog record
| CREATOR | Heci Zhao, Xiaotian Fu, Xiuyan Ding, Liqian Zhu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 22 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |