Mutant p53-Mediated Tumor Secretome: Bridging Tumor Cells and Stromal Cells
Lei Qiu, Zelong Ma, Xiaoming Wu · 2024
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Description
A gene called p53 acts as a guard against cancer, and broken forms of it are found in many tumors. Lei Qiu, Zelong Ma, and Xiaoming Wu review, in a 2024 paper, how mutant p53 changes what tumor cells release into their surroundings. Those released proteins carry signals between cancer cells and the support cells around them.
The review explains how mutant p53 reshapes both the mix of released proteins and the paths that send them out. That reshaping helps build a tumor-friendly setting, speeds growth, and shifts how nearby fibroblasts and immune cells behave. By mapping these signals, the authors look for weak points that new cancer drugs could target. The paper links a single gene fault to wide effects across the whole tumor.
Catalog record
| CREATOR | Lei Qiu, Zelong Ma, Xiaoming Wu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |