Unveiling the Complexity of KMT2A Rearrangements in Acute Myeloid Leukemias with Optical Genome Mapping
Sandrine A. Lacoste, Vanessa Gagnon, François Béliveau, Sylvie Lavallée, Vanessa Collin, Josée Hébert · 2024
Read Unveiling the Complexity of KMT2A Rearrangements in Acute Myeloid Leukemias with Optical Genome Mapping by Sandrine A. Lacoste, Vanessa Gagnon, François Béliveau, Sylvie Lavallée, Vanessa Collin, Josée Hébert (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674939.txt.
Description
Sandrine Lacoste and co-authors test in 2024 a genome imaging method on hard-to-read gene changes in a blood cancer. Rearrangements of the KMT2A gene help classify acute myeloid leukemias and now guide a new class of drugs, yet many are hidden or tangled, and one form escapes standard tests entirely.
Optical genome mapping read thirty-eight samples: twelve hidden fusions, twenty partial duplications, and six clean cases. In every fusion case it found the swap and its partner gene. The duplications proved surprisingly varied, with nine distinct forms once RNA data were added. The authors back the method for exact diagnosis.
Catalog record
| CREATOR | Sandrine A. Lacoste, Vanessa Gagnon, François Béliveau, Sylvie Lavallée, Vanessa Collin, Josée Hébert |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |