The serotonergic psychedelic N,N-dipropyltryptamine alters information-processing dynamics in in vitro cortical neural circuits
Thomas F. Varley, Daniel Havert, Leandro Fosque, Abolfazl Alipour, Naruepon Weerawongphrom, Hiroki Naganobori, Lily O’Shea, Maria Pope, John Beggs · 2024
Read The serotonergic psychedelic N,N-dipropyltryptamine alters information-processing dynamics in in vitro cortical neural circuits by Thomas F. Varley, Daniel Havert, Leandro Fosque, Abolfazl Alipour, Naruepon Weerawongphrom, Hiroki Naganobori, Lily O’Shea, Maria Pope, John Beggs (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674936.txt.
Description
Thomas Varley and co-authors dose lab-grown cortical circuits with a psychedelic and watch their information flow change. Most psychedelic neuroscience scans whole human brains, leaving the middle scale of circuits unexplored. Here the drug is N,N-dipropyltryptamine, a serotonin-based psychedelic, applied to rat cortical tissue cultures.
Electrodes recorded three hours of spontaneous activity: one hour clean, one hour with the drug, one hour washed out. The drug reversibly altered how information was processed and shared across the circuit. Dish-grown networks let researchers isolate drug action from expectation and setting, the confounds of human studies. Findings at this scale may anchor theories built from brain scans.
Catalog record
| CREATOR | Thomas F. Varley, Daniel Havert, Leandro Fosque, Abolfazl Alipour, Naruepon Weerawongphrom, Hiroki Naganobori, Lily O’Shea, Maria Pope, John Beggs |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |