Discovery of Carbonic Anhydrase 9 as a Novel CLEC2 Ligand in a Cellular Interactome Screen
Sebastian Hoffmann, Benedict-Tilman Berger, Liane Rosalie Lucas, Felix Schiele, John Edward Park, Matthias Buck · 2024
Read Discovery of Carbonic Anhydrase 9 as a Novel CLEC2 Ligand in a Cellular Interactome Screen by Sebastian Hoffmann, Benedict-Tilman Berger, Liane Rosalie Lucas, Felix Schiele, John Edward Park, Matthias Buck (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674933.txt.
Description
Sebastian Hoffmann and co-authors fished for new partners of a cancer linked surface protein in 2024, using a library of nearly all human membrane protein outer parts. Such proteins run cell communication and make prime drug targets, yet many of their handshakes stay unknown.
Screening the library against immune cells surfaced a surprise: the cancer protein touches a platelet receptor famous for clotting signals. A five letter patch on the cancer protein, identical to the patch on the receptor's one known partner, proved to be the grip. A blood cancer cell line carrying the protein naturally could fire the receptor's signal. The finding hands cancer biology a new suspect interaction, and the library a proof of worth.
Catalog record
| CREATOR | Sebastian Hoffmann, Benedict-Tilman Berger, Liane Rosalie Lucas, Felix Schiele, John Edward Park, Matthias Buck |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |