Inflammatory Response of THP1 and U937 Cells: The RNAseq Approach
Layla Panahipour, Chiara Micucci, Reinhard Gruber · 2024
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Description
Layla Panahipour, Chiara Micucci, and Reinhard Gruber published a cell study in 2024. They compared two lab cell lines used in inflammation research. Both lines come from human blood-related cancers. Labs use them to stand in for immune cells. Their responses to triggers are not identical, though. No agreed gene panel marked inflammation in both. The team used RNA sequencing to settle this. Cells were exposed to two strong inflammatory triggers.
Strict cutoffs revealed clearly regulated gene sets. One line responded much more strongly overall. The other line changed fewer genes in total. Some classic inflammation genes rose in both lines. Others rose in only one line each time. The lists give labs a firmer reference point. Choosing the right line matters for each question. Shared genes offer the safest common readout.
Catalog record
| CREATOR | Layla Panahipour, Chiara Micucci, Reinhard Gruber |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |