Adipose-Derived Mesenchymal Stem Cells (ADSCs) Have Anti-Fibrotic Effects on Lung Fibroblasts from Idiopathic Pulmonary Fibrosis (IPF) Patients
Noriko Ouji-Sageshima, Aiko Hiyama, Makiko Kumamoto, Masahiro Kitabatake, Atsushi Hara, Ryutaro Furukawa, Shigeto Hontsu, Takeshi Kawaguchi, Noriyoshi Sawabata, Shigeo Muro, Toshihiro Ito · 2024
Read Adipose-Derived Mesenchymal Stem Cells (ADSCs) Have Anti-Fibrotic Effects on Lung Fibroblasts from Idiopathic Pulmonary Fibrosis (IPF) Patients by Noriko Ouji-Sageshima, Aiko Hiyama, Makiko Kumamoto, Masahiro Kitabatake, Atsushi Hara, Ryutaro Furukawa, Shigeto Hontsu, Takeshi Kawaguchi, Noriyoshi Sawabata, Shigeo Muro, Toshihiro Ito (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674916.txt.
Description
Stem cells taken from a patient's own fat calmed scar forming lung cells in the dish, report Noriko Ouji-Sageshima and co-authors in a 2024 study. The disease in view is idiopathic pulmonary fibrosis, a progressive lung scarring with a median survival of three years and no effective drug therapy.
Lung cells from patients, grown beside the fat derived stem cells, turned down their fibrosis genes. The stem cells raised a brake protein that quiets a growth signal inside the lung cells. Given through a vein, the cells also eased scarring in mice with drug induced lung injury. The authors offer the cells as a treatment candidate.
Catalog record
| CREATOR | Noriko Ouji-Sageshima, Aiko Hiyama, Makiko Kumamoto, Masahiro Kitabatake, Atsushi Hara, Ryutaro Furukawa, Shigeto Hontsu, Takeshi Kawaguchi, Noriyoshi Sawabata, Shigeo Muro, Toshihiro Ito |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |