A Phthalimide-Functionalized Heptamethine Cyanine Dye for Tumor-Targeted Photothermal Therapy
Yoonbin Park, Juhui Yang, Hoon Hyun · 2024
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Description
Yoonbin Park, Juhui Yang, and Hoon Hyun report, in twenty twenty-four, a new dye that both marks tumors and heats them to kill cancer. The dye is a near-infrared fluorescent dye, which glows under light the eye cannot see. Its stiff ring shape lets it gather in tumors on its own, with no added targeting part. That is a design the authors call structure-inherent targeting. They built and tested the dye in mice with human colon tumors.
Two days after injection, the dye had built up strongly in tumors versus other tissue. A laser then heated the tumors for five minutes. Growth was blocked compared with controls. No regrowth or deaths from the dye were seen in follow-up.
Catalog record
| CREATOR | Yoonbin Park, Juhui Yang, Hoon Hyun |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |