The Cancer Chimera: Impact of Vimentin and Cytokeratin Co-Expression in Hybrid Epithelial/Mesenchymal Cancer Cells on Tumor Plasticity and Metastasis
Nick A Kuburich, Julia M Kiselka, Petra den Hollander, Andrew A Karam, Sendurai A Mani, David Wong · 2024
Read The Cancer Chimera: Impact of Vimentin and Cytokeratin Co-Expression in Hybrid Epithelial/Mesenchymal Cancer Cells on Tumor Plasticity and Metastasis by Nick A Kuburich, Julia M Kiselka, Petra den Hollander, Andrew A Karam, Sendurai A Mani, David Wong (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674825.txt.
Description
Cancer spreads when cells change character, loosening their grip and learning to move. Nick Kuburich and co-authors reviewed in 2024 a rare halfway state in that change, where cells carry markers of both their old and new forms. These hybrid cells, scarce in healthy adult tissue, move and seed new tumors better than cells at either end of the change, which makes them promising warning signs and drug targets.
Two fiber proteins mark the hybrid state: one typical of surface cells and one of moving cells. The review covers what each fiber does alone, how they may interact when they appear together, and whether fibers reach the cell surface where drugs could reach them.
Catalog record
| CREATOR | Nick A Kuburich, Julia M Kiselka, Petra den Hollander, Andrew A Karam, Sendurai A Mani, David Wong |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |