DHODH Inhibition Suppresses MYC and Inhibits the Growth of Medulloblastoma in a Novel In Vivo Zebrafish Model
Ioanna Tsea, Thale Kristin Olsen, Panagiotis Alkinoos Polychronopoulos, Conny Tümmler, David B Sykes, Ninib Baryawno, Cecilia Dyberg, Geoffrey J Clark · 2024
Read DHODH Inhibition Suppresses MYC and Inhibits the Growth of Medulloblastoma in a Novel In Vivo Zebrafish Model by Ioanna Tsea, Thale Kristin Olsen, Panagiotis Alkinoos Polychronopoulos, Conny Tümmler, David B Sykes, Ninib Baryawno, Cecilia Dyberg, Geoffrey J Clark (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11674817.txt.
Description
Ioanna Tsea and co-authors test a drug that may weaken the hardest form of a childhood brain tumour, in a 2024 paper. Medulloblastoma is the most common high-grade brain tumour in children, and its group 3 form has the worst outlook. Many group 3 tumours overproduce MYC, a growth-driving protein that drugs have failed to block directly. The team instead blocked an enzyme the tumour needs to build DNA parts.
The drug, brequinar, jams that enzyme, called DHODH. The authors first found the enzyme running high in group 3 and a second tumour subgroup, where it tracked with MYC and poor survival. They then tested the drug on seven tumour cell lines in dishes. Finally, they built a new zebrafish model carrying the tumour to watch the drug's effect and safety in a living body, a step toward trials in children.
Catalog record
| CREATOR | Ioanna Tsea, Thale Kristin Olsen, Panagiotis Alkinoos Polychronopoulos, Conny Tümmler, David B Sykes, Ninib Baryawno, Cecilia Dyberg, Geoffrey J Clark |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |